Nature：與膀胱癌有關(guān)的頻發(fā)突變

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　　導(dǎo)讀：對131個(gè)高等級肌肉入侵性尿路上皮膀胱癌所做的這項(xiàng)研究(癌癥基因組圖集 (TCGA)項(xiàng)目的一部分)，報(bào)告了32個(gè)基因的頻發(fā)突變，其中包括那些在細(xì)胞周期調(diào)控、染色質(zhì)調(diào)控和激酶信號(hào)作用通道中所涉及的基因。

　　染色質(zhì)調(diào)控基因在尿路上皮癌中發(fā)生突變的頻率比在迄今所研究的任何常見癌癥中都高。 頻發(fā)in-frame激發(fā)FGFR3-TACC3融合以及與基因失活相關(guān)的病毒的表達(dá)或整合在這項(xiàng)研究中也被發(fā)現(xiàn)。重要的是，在69%的這些腫瘤中還發(fā)現(xiàn)了潛在的治療目標(biāo)。

　　推薦的英文摘要

　　Nature doi:10.1038/nature12965

　　Comprehensive molecular characterization of urothelial bladder carcinoma

　　The Cancer Genome Atlas Research Network

　　Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150，000 deaths per year worldwide. So far， no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project， we report here an integrated analysis of 131 urothelial carcinomas to provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes， including multiple genes involved in cell-cycle regulation， chromatin regulation， and kinase signalling pathways， as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes， two of which (papillary-like and basal/squamous-like) were also evident in microRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours， including 42% with targets in the phosphatidylinositol-3-OH kinase/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far， indicating the future possibility of targeted therapy for chromatin abnormalities.

　　膀胱癌如何治療？膀胱癌的治療藥物有：意美（阿瑞匹坦片）、金刺參九正合劑、阿魏化痞膏等藥物進(jìn)行輔助治療。

　　詳情請致電我們的客服垂詢：400-101-6868。如需購買意美（阿瑞匹坦片）、金刺參九正合劑、阿魏化痞膏，可到臨近門店。成都2家分店地址分別為：成都市青羊區(qū)文武路158號(hào)，門店電話：028-86722949;028-86725308。成都市武侯區(qū)玉林北街1號(hào)附7、8號(hào) 玉林品上1層商鋪。（一環(huán)路九茹村好又多背面）。門店電話：028-85033975

　　腫瘤科藥師溫馨提醒：晚期腫瘤侵犯膀胱周圍組織、器官或有盆腔淋巴結(jié)轉(zhuǎn)移時(shí)導(dǎo)致膀胱區(qū)疼痛、尿道陰道瘺、下肢水腫等相應(yīng)癥狀，遠(yuǎn)處轉(zhuǎn)移時(shí)也可出現(xiàn)轉(zhuǎn)移器官功能受損、骨痛及惡液質(zhì)等表現(xiàn)。

TAG：膀胱癌 腫瘤