The efficacy and tolerability of Hirudoid forte as gel and cream were studied in 513 patients with superficial venous disorders or haematoma. The efficacy was assessed on the basis of a special score (Schone).

    Schone研究了特強(qiáng)喜療妥凝膠和軟膏的療效和耐受性，受試對(duì)象為513例淺表靜脈疾病或血腫患者。通過(guò)特定的評(píng)分制對(duì)療效進(jìn)行了評(píng)估。

 

    The following tables show the results of treatment. Cream and gel showed a similar effcacy in the different indications. The patients reported the pleasant cooling effect of the gel. The tolerability of Hirudoid forte cream and gel was equally good.

    下附的結(jié)論顯示了療效。對(duì)于不同的適應(yīng)癥，軟膏和凝膠的療效是相似的。患者反應(yīng)凝膠的清涼效果另人愉快。特強(qiáng)喜療妥軟膏和凝膠耐受性都相當(dāng)好。

 

    Levai reported on 243 patients who were treated with Hirudoid gel for different venous disorders of the lower extremities. The efficacy was judged according to the following parameters: status of pain, sensation of tension, absorption of infiltrates and haematomas, and period of time until subsidence of symptoms.

    Levai報(bào)道了用喜療妥凝膠治療243位末梢靜脈疾病患者。療效是通過(guò)以下參數(shù)評(píng)估的：疼痛程度、張力、滲出和血腫的吸收以及癥狀緩解所需的時(shí)間。

 

    After only 7 days of treatment about 72 to 97% of the patients depending on the specific disorder were without symptoms. The author emphasized the excellent tolerability of the product.

    僅僅治療7天后，由于疾病的不同，72％至97％的患者癥狀消失。作者強(qiáng)調(diào)了產(chǎn)品的耐受性極佳。

 

    Alter used Hirudoid gel for the treatment of 188 patients suffering from varicosities, haematomas and acute phlebitis. The author emphasized the fact that complete freedom from the complaints was already observed after a few days. In the cases of varicosis or thrombophlebitis for which the results of therapy were indicated as very good, freedom from pain was achieved after only 3-5 days. Swelling and erythema receded after a few days. Even large haematomas responded successfully; they were completely absorbed within a week. Hirudoid gel was very well tolerated. The speedy penetration into the skin and the cooling action were felt to be particularly pleasant.

    Alter應(yīng)用喜療妥凝膠治療了共188位靜脈曲張、血腫和急性靜脈炎患者。作者強(qiáng)調(diào)僅僅用藥很少幾天后癥狀就完全緩解了。對(duì)于靜脈曲張或血栓性靜脈炎的療效非常好，疼痛的緩解僅需用藥3－5天。水腫和紅斑也于用藥很少幾天后減輕了。甚至很大的血腫對(duì)于藥物的反應(yīng)亦非常成功，它們?cè)谝恢軆?nèi)完全吸收了。喜療妥凝膠的耐受性非常良好。特別是其對(duì)于皮膚的快速滲透和清涼作用特別令人愉快。

 

    Grotz used Hirudoid forte cream for the treatment of 244 patients with superficial phlebitis (n = 118), haematomas (n = 55), and painful varicosis with a risk of thrombophlebitis (n = 71). Depending on the specific disorder, the treatment lasted for 6-15 days. Parameters for the assessment of success of therapy were the cardinal symptoms of inflammation: swelling, reddening, increase of body temperature, spontaneous pain and pain on pressure. In patients with haematomas besides the status of pain, the extension and discoloration of the effusions were assessed. The mode of administration massage of the cream into the skin or cream dressing had no influence on the result of treatment; the tolerability was considered to be very good.

    Grotz用特強(qiáng)喜療妥軟膏治療了244位患者，其中淺表靜脈炎患者118例，血腫患者55例和疼痛性靜脈曲張并有發(fā)展為血栓性靜脈炎傾向的患者71例。根據(jù)不同的疾病，治療持續(xù)了6－15天。以炎癥的主要癥狀作為療效的評(píng)估參數(shù)：水腫、充血、皮溫升高、自發(fā)性疼痛和壓力性疼痛。血腫患者除了疼痛的程度，還評(píng)估了滲出的范圍和色澤。將軟膏按摩入皮膚的方式或軟膏敷料對(duì)療效無(wú)影響，藥物的耐受性非常良好。

 

In a retrospective study in 45 patients O''Herlihy compared the influence of Hirudoid cream with oral analgesics and anti-inflammatory agents on superficial thrombophlebitis caused by pregnancy. The clinically relevant characteristics of the group treated with Hirudoid (23 patients) and the control group (22 patients) were comparable. There were statistically significant differences with regard to the duration of pain (p < 0.001) and symptoms of inflammation (p < 0.01) in favour of the Hirudoid group. Although the evidence has been evaluated retrospectively, these data suggest that the local action of Hirudoid cream provides more rapid relief than traditional treatment with orally-administered anti-inflammatory analgetics. It therefore appears to be a useful adjunct in the management of superficial thrombophlebitis in the legs

在一回顧性研究中，O''Herlihy比較了喜療妥軟膏和口服止痛劑及消炎藥對(duì)于45位因懷孕而引起的淺表血栓性靜脈炎患者的療效。喜療妥治療組（23例患者）和對(duì)照組（22例患者）的相關(guān)臨床特征具有可比性。

 

Florian reported on the favorable results achieved with Hirudoid cream in the treatment of inflammatory venous disorders in 98 outpatients of a phlebological clinic. The efficacy of the treatment in regard to the symptoms of pain, tiredness and feeling of heaviness of the legs were impressive for the patient. In addition, an improvement of the parameters such as swelling, induration and pigmentation could be verified.

Florian報(bào)道用喜療妥軟膏治療98位患有靜脈疾病的門診患者，療效令人滿意。患者對(duì)于藥物有關(guān)改善疼痛和腿部疲憊及沉重感的療效印象深刻。此外，還證實(shí)藥物能改善水腫、硬化和色素沉著。

 

In a further published study the same author confirms the great efficacy of Hirudoid and Hirudoid forte in the treatment of 90 patients with venous, inflammatory and traumatic diseases of the lower extremities. In the case of severe and recurrent complaints patients were treated with the product containing the higher dose, i.e. Hirudoid forte. Doppler sonography and skin thermometry were used in 10 patients to verify the assessment of the success of the treatment. Doppler sonography confirmed the clinical assessment of the therapeutic success.

在所發(fā)表的進(jìn)一步的研究中，該作者還證實(shí)了喜療妥和特強(qiáng)喜療妥在治療肢體末端靜脈炎癥的卓越療效，共有90例患者接受了治療。對(duì)于那些癥狀嚴(yán)重的復(fù)發(fā)病例用高濃度藥物治療，如特強(qiáng)喜療妥。為了進(jìn)一步證實(shí)和評(píng)估藥物的有效性，對(duì)其中的10位患者進(jìn)行了多譜勒超聲和皮溫測(cè)試。多譜勒超聲檢查證實(shí)了臨床驗(yàn)證的治療有效性。

 

Cutaneous thermometry makes it possible to verify the course of an inflammatory process and the anti-inflammatory action of specific drug therapies. In this study, thermometry showed that the temperature of the inflamed tissue was decreased as a result of treatment.

皮溫測(cè)定使對(duì)炎癥發(fā)展過(guò)程和特定制劑的抗炎作用的監(jiān)測(cè)成為可能。在這項(xiàng)研究中，皮溫測(cè)試顯示炎癥組織的溫度由于治療而降低了。

 

Compression and the use of topical preparations represent the basic therapy for many venous disorders. The excellent tolerability of Hirudoid and Hirudoid forte is therefore of particular importance.

局部壓迫和外用制劑是許多靜脈疾病的基礎(chǔ)治療。喜療妥和特強(qiáng)喜療妥由于其極好的耐受性而特別重要。

 

In an open multicentre study 813 patients were treated with Hirudoid cream, who suffered from varicose syndrome (varicose veins, venous congestion, spider varicosities, follow-up of vein stripping, thrombophlebitis, infusion phlebitis), acute posttraumatic conditions (contusions, strains, haematomas) and scars (Eckenberger/van Aubel).A thin layer of cream was applied to the affected region once or several times daily and gently massaged in.

Eckenberger/van Aubel在一開放性研究中，用喜療妥軟膏治療813位患者，他們分別患有腫脹綜合癥（靜脈曲張、靜脈充血、蜘蛛狀靜脈曲張、繼發(fā)性靜脈脫膜、血栓性靜脈炎、輸注性靜脈炎）、急性外傷（檫傷、扭傷和血腫）和疤痕。一天一次或數(shù)次在患處薄薄地涂一層，并輕輕按摩入皮膚。

 

The criteria for the assessment of efficacy were pain at rest, pain on pressure and movement, feeling of tension and heaviness, edema, leg cramps, haematoma, erythema, palpable indurations, duration of treatment up to improvement and up to freedom from symptoms and signs and global assessment.

療效的評(píng)估標(biāo)準(zhǔn)包括：靜止性疼痛、壓力和運(yùn)動(dòng)性疼痛、張力和沉重感、水腫、腿部抽筋、血腫、紅斑、可觸及硬化、癥狀和體癥緩解和痊愈所需的時(shí)間，全球評(píng)估標(biāo)準(zhǔn)。

 

On the average improvement was seen at the end of a week. Complete freedom from symptoms and signs was achieved in 84% of patients at the end of a fortnight. Chronic venous disorders and scar formation required longer treatment. The investigating physicians assessed the skin tolerability of Hirudoid and Hirudoid forte as good or very good in 97,3 % of all cases.

癥狀和體癥改善所需的平均時(shí)間為一周。兩周時(shí)84％的患者癥狀和體癥完全消失。慢性靜脈疾病和疤痕形成所需治療期較長(zhǎng)。調(diào)查醫(yī)師對(duì)喜療妥或特強(qiáng)喜療妥的皮膚耐受性評(píng)價(jià)為好或非常好的病例百分比為97.3％。

 

Taterka treated 68 cases of acute varicophlebitis, varicose thrombophlebitis, inflammatory conditions following phlebosclerosation and conditions following thrombectomy with Hirudoid cream and long-term compression bandages. Within the one week therapy with Hirudoid the inflammatory signs in all patients had either completely subsided or had improved to such an extent that a complete healing was achieved. Scar formation was avoided, and disfiguring pigmentation in the paravenous connective tissue was hardly ever observed.

Taterka用喜療妥軟膏和長(zhǎng)期繃帶壓迫治療了68例急性靜脈曲張、曲張性血栓性靜脈炎、靜脈硬化繼發(fā)炎癥和血栓切除術(shù)后患者。在用喜療妥治療的一周期間，所用患者的炎癥均顯著減輕或痊愈了。并且避免了疤痕的形成，而且?guī)缀鯖](méi)有觀察到結(jié)締組織有色素沉著。

 

The simple and safe therapy with Hirudoid was stressed in particular; symptoms of irritation were not observed in any of the cases. The excellent results of treatment of varicose thrombophlebitis indicate that compression bandaging with Hirudoid cream may be used for routine prophylaxis of inflammatory reactions and for the improvement of cosmetic results after sclerotherapy of varicose veins.

研究者特別強(qiáng)調(diào)了用喜療妥治療方便、安全，未在任何病例觀察到有刺激癥狀。研究結(jié)論顯示，喜療妥軟膏聯(lián)合繃帶壓迫治療曲張性血栓性靜脈炎療效卓越，可以作為靜脈曲張術(shù)后的預(yù)防炎癥反應(yīng)和促進(jìn)術(shù)后恢復(fù)。

 

Klempa/Balser, who had treated 112 patients with Hirudoid gel after vein stripping, confirmed :"Hirudoid gel makes it possible to considerably reduce the postoperative period of healing after vein stripping." In this study the postoperative period of healing was reduced by more than 50% as a result of the treatment with Hirudoid.

Klempa和Balser用喜療妥凝膠治療了112例靜脈脫膜患者后證實(shí)：“喜療妥凝膠使靜脈脫膜術(shù)后的痊愈時(shí)間顯著縮短了”。在這項(xiàng)研究中，用喜療妥治療后，術(shù)后恢復(fù)至痊愈所需的時(shí)間縮短了至少50％。

 

The efficacy of Hirudoid was verified in particular in those patients who had had operations at both legs during one session. Although the results of surgery were comparable at the legs, the leg treated with Hirudoid healed approximately twice as fast as the other leg.

特別是對(duì)于那些雙腿同時(shí)接受手術(shù)的患者，喜療妥的療效得到了進(jìn)一步驗(yàn)證。雖然手術(shù)狀況在雙腿具有可比性，用喜療妥治療側(cè)腿部的痊愈時(shí)間大約是對(duì)側(cè)的兩倍。

 

No local reactions as result of the treatment with Hirudoid were observed.

未觀察到因應(yīng)用喜療妥治療而引起的局部反應(yīng)。