芳香化酶抑制劑來曲唑或者可以治療腦癌

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　　導讀：辛辛那提大學（UC）研究人員希望能夠重新利用常用乳腺癌藥物，來針對惡性原發性腦腫瘤如神經膠質瘤開展治療。

　　Pankaj Desai博士等人重新利用芳香化酶抑制劑（一類廣泛應用于絕經后婦女乳腺癌治療的藥物），來尋找腦癌治療藥物，結果發現先導化合物來曲唑（letrozole）具有巨大的治療潛力。

　　利用腦腫瘤組織樣本進行的研究，證實某些芳香化酶抑制劑藥物可能對腦腫瘤具有顯著治療效益。目前的工作重點放在先導化合物--來曲唑上，其是一種口服藥物。

　　因為原發性腦癌的發病率和死亡率都較高，因此治療迫切需要獲得突破性發現。由于研究課題是如此有前途的，加州大學知識產權局申請了專利。 該小組目前正在積極設計早期臨床試驗。如果證實藥物來曲唑對腦癌有效，將可以在短短兩三年內上市。

　　英文原文報導：

　　Researchers look at breast cancer drugs to treat certain brain tumors

　　University of Cincinnati (UC) researchers hope to repurpose commonly used breast cancer medicines for the treatment of malignant primary brain tumors such as gliomas.

　　We have an early discovery with the tremendous potential to cure, says Pankaj Desai, PhD, a professor of pharmacokinetics and drug metabolism at the UC James L. Winkle College of Pharmacy who is leading the effort at UC to repurpose aromatase inhibitors, a class of drugs extensively used in the treatment of breast cancer in post-menopausal women.

　　Ongoing research in brain tumor tissue samples suggests that these agents could be strikingly effective on brain tumors, says Desai, a member of the UC Cancer Institute with over 20 years'' experience in oncology drug development.

　　The current efforts are focused on the lead compound letrozole, an orally administered drug with an outstanding record of safe use.

　　There is a desperate need for a breakthrough in the treatment of primary brain tumors as they have high rates of morbidity and mortality, says Desai.

　　The study started as a dissertation research project of Nimita Dave, who completed her PhD at the Winkle College of Pharmacy in April 2014 under Dr. Desai and has continued her work with him as a postdoctoral fellow. Their research project is so promising that the UC Intellectual Property office has filed a patent application and Desai and his team were recently awarded a $40,000 incubator grant from the University of Cincinnati Technology Commercialization Accelerator in order to develop the administrative protocol to take letrozole to clinical trial.

　　The team is also working closely with neuro-oncologists Lionel Chow, MD, PhD, Cincinnati Children''s Hospital Medical Center, Richard Curry, MD, and John Morris, MD, UC College of Medicine, on designing early clinical trials.

　　According to Desai, who is the director of the college''s master''s program in drug development, because the project involves the repurposing an existing drug, with additional funding a clinical trial could start as early as 2015-and if proven effective the drug could go to market in as few as two to three years.

　　腦癌如何治療？腦癌的治療藥物可以選擇：鴉膽子油軟膠囊、鴉膽子油口服乳液、安康欣膠囊等藥物進行治療的。

　　詳情請致電我們的客服垂詢：400-101-6868。如需購買鴉膽子油軟膠囊、鴉膽子油口服乳液、安康欣膠囊，可到臨近門店。廣州腫瘤店地址為：廣州市越秀區先烈南路21號之一（中山大學腫瘤醫院中門斜對面）。通過GSP質量認證的藥房，獲廣州市藥品經 營誠信企業和工商局頒發的消費者信得過商家稱號。門店電話：020-87303808。

　　腫瘤科藥師溫馨提醒：腦瘤晚期癥狀，腦腫瘤是一種腦部的腫瘤，應該注意及早的治療，注意合適的方法，注意晚期癥狀的了解，早期的治療對于患者會有著很大的幫助，所以要注意早期的治療，注意合理方式。

TAG：腦癌 腫瘤